منابع مشابه
Merkel cell carcinoma and HIV infection.
Merkel cell carcinoma (MCC) is a rare skin cancer that occurs more frequently after organ transplantation or B-cell malignancy, conditions of suppressed or disordered immunity. To assess further whether immune suppression increases MCC risk, we studied its occurrence in a cohort of 309365 individuals with acquired immunodeficiency syndrome (AIDS) by using linked AIDS and cancer registries. We i...
متن کاملmerkel cell polyomavirus infection in a patient with merkel cell carcinoma: a case report
conclusions the findings of this study are consistent with the hypothesis that local, systemic, or tumor-induced immunosuppression may allow the mcpyv to initiate skin aggressive cancer. it is necessary to maintain regular check over patients taking immunosuppressive medications for mcpyv infection. since there is not any information about detection and molecular biology analysis of mcpyv among...
متن کاملMerkel cell polyomavirus infection and host defence in patients with Merkel cell carcinoma
Background and purpose: Merkel cell carcinoma (MCC) is a rare and often aggressive skin cancer that usually arises in elderly individuals. MCC is frequently associated with ultraviolet radiation exposure and immunosuppressive conditions. The majority of MCCs harbor Merkel cell polyomavirus (MCPyV), a newly discovered human cancer virus. Several studies have indicated its importance in MCC tumor...
متن کاملMerkel cell polyomavirus infection, large T antigen, retinoblastoma protein and outcome in Merkel cell carcinoma.
PURPOSE Merkel cell carcinoma (MCC) is rare skin cancer that is often associated with Merkel cell polyomavirus (MCPyV) infection. Polyomaviruses repress tumor suppressor proteins, thus influencing cell-cycle progression, but the effect of MCPyV on the key cell-cycle regulating proteins is poorly understood. EXPERIMENTAL DESIGN We evaluated expression of the MCPyV large T-antigen (LTA), Ki-67,...
متن کاملRe: Clinical factors associated with Merkel cell polyomavirus infection in Merkel cell carcinoma.
Sihto et al. ( 1 ) recently analyzed 114 formalinfixed and paraffin-embedded Merkel cell carcinoma (MCC) samples from a Finnish cohort for the presence of Merkel cell polyomavirus (MCPyV) DNA. They reported that the prevalence of MCPyV DNA in MCC was 79.8% and, surprisingly, that MCPyV DNA – positive MCCs were preferentially located on the limbs compared with MCPyV DNA – negative MCCs. Their da...
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ژورنال
عنوان ژورنال: The Lancet
سال: 2002
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(02)07668-7